clobetasol cream


Clobetasol (kloe bay ta sol)

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The drug clobetasol is a topical steroid which reduces the actions of chemicals in the body that cause inflammation, swelling and redness. The drug is used to treat inflammation and itching caused by a number of skin conditions such as allergic reactions, eczema and psoriasis.

Quantity Strength Unit Price Price Cart
1 Tube Temovate .05% Ointment (15gm Tube) $5.40 $5.40
3 Tubes Temovate .05% Ointment (15gm Tube) $5.07 $15.20


The precise mechanism of action of anti-inflammatory topical steroids is the treatment of steroid-responsive dermatose. Corticosteroids thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. These proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.Clobetasol bind to the glucocorticoid receptor, which enters the cell nucleus and modifies genetic transcription.


How to use:A small amount of medicine is applied to the affected area. The medicine is rubbed gently. The hands are washed immediately after applying Temovate cream. The affected area should not be bandaged or wrapped. Treatment is provided for 2 consecutive weeks.


  • The drug is used to reduce itching, redness and swelling associated with the skin conditions.
  • The drug is used in the treatment of eczema and psoriasis.
  • It is also used to treat several auto-immune diseases including alopecia areata, vitilligo and lichen planus(auto immune skin nodules) and mycosis fungoides.

Drug interactions:

The drug shows following kind of drug interactions:

  • Aldesleukin: The drug corticosteroids such as clobetasol can diminish the antineoplastic effect of aldesleukin. The concurrent use of corticosteroids with aldesleukin is avoided.
  • Telaprevir: Corticosteroids such as clobetasol may decrease the serum concentration of Telaprevir. Telaprevir can increase the serum concentration of corticosteroids. The concurrent use of Telaprevir and systemic corticosteroids is not recommended.


The drug is strictly contraindicated in the following cases:

Temovate cream and ointment are contraindicated in the patients who have history of hypersensitivity to any of the components of the preparations.


Some of the precautionary measures that should be taken into consideration while the usage of this drug are:

  • If the female is pregnant, or planning to become pregnant or under breast feeding condition.
  • If the person is having any allergy to medicines, foods or other substances.
  • If the person has measles, tuberculosis or had a recent vaccination.
  • If the person has any skin infection or thinning of the skin (atrophy).
  • Contact with the eyes should be avoided.
  • The drug should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Side effects:

The side effects of the drug include:

  • If any allergic reaction appears like hives, difficulty in breathing, swelling of lips, tongue or throat.
  • If severe irritation of treated skin is found, take the medication help immediately.
  • Dry or cracking skin, thinning or softening of the skin, rashes on skin or irritation around the mouth, temporary hair loss, spider veins, swollen hair follicles, weight gain, puffiness in the  face.


Overdosing of the medication should not be done. Long term use of high steroid doses can lead to symptoms such as thinning skin, easy bruising, and changes in the shape or location of body fat, increased acne or facial hair, menstrual problems, impotence, loss of interest in sex.

Missed does:

If a dose is missed, take it as soon as get remember. But if it has been the time of next dose, the missed dose is skipped and the regular dosing schedule is followed.

Storage conditions:

The drug should be stored at room temperature at 20 to 25oC in a tightly closed container. The drug should be stored away from heat, moisture and light. Keep the drug out of reach of children and pets.

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