Danazol

Danazol

Danocrine

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$0.67

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Danazol

is a derivative of the synthetic steroid ethisterone that suppresses the production of gonadotropins and has some weak androgenic effects. It exhibits hypoestrogenic, hyperandrogenic effects that cause atrophy of the endometrium, which can alleviate the symptoms of endometriosis. It prevents ovulation by suppressing the increase of luteinizing hormone during the middle of the menstrual cycle. Danazol inhibits ovarian steroidogenesis resulting in decreased secretion of estradiol and can increase androgens. Danazol displaces testosterone from sex hormone-binding globulin (SHBG), displacing it and increasing serum testosterone levels.

Quantity Strength Unit Price Price Cart
30 Capsules Danocrine (Danazol) 50mg $0.72 $21.60
90 Capsules Danocrine (Danazol) 50mg $0.67 $60.00
30 Capsules Danocrine 100mg. $0.80 $24.00
90 Capsules Danocrine 100mg. $0.80 $72.00
30 Capsules Danocrine (Danazol) 200mg $1.54 $46.20
90 Capsules Danocrine (Danazol) 200mg $1.53 $138.00

Details

Danazol is a synthetic steroid which works by decreasing the level of certain hormones, which reduces the symptoms and severity of diseases that are treated by Danazol.This drug acts by means of its antigonadotrophic effects on the pituitary, however, a review of the literature reveals that its efficacy in suppressing normal endometrial growth and in causing atrophy of deposits of endometrium .

How to use danazol:

The drug danazol is taken by mouth with or without food. If endometriosis or fibrocystic breast disease occurs, the treatment should beginduring menstruation. The drug should be taken consistently for 3 to 6 months. It may be necessary to take danazol for 9 months.

Dosage of danazol:

In moderate to severe disease, a starting dose of 800 mg given in two divided doses is recommended. For mild cases, an initial daily dose of 200mg to 400 mg given in two divided doses is recommended.

Uses of danazol:

The drug danazol is used for:

  • Treating certain types of endometriosis or fibrocystic breast disease.
  • The drug is also used to prevent attacks of hereditary angioedema(HAE)

Drug interactions of danazol:

The drug interactions shown by this medication are:

  • Anticoagulants e.g. warfarin. Carbamazepine, cyclosporine, sirolimus, certain statins(e.g. atorvastatin, lovastatin) or Tacrolimus.
  • Insulin or other diabetes medicines (e.g. glipizide) because its effectiveness may be decreased by danazol.

Contraindications of danazol:

The drug danazol is strictly contraindicated to the following cases:

  • If the person is allergic to any ingredient of danazol.
  • If the woman is pregnant or breastfeeding.
  • If the woman has undiagnosed abnormal vaginal bleeding.
  • If the person have blood disease porphyria, an androgen-dependent tumor, or severe liver,kidney or heart problems.
  • If the person has a blood clot, or have a history of blood clots or stroke.
  • If the person is taking simvastatin.
  • The drug is contraindicated in patients having liver disease because it can masculinize a female fetus.

Precautions of danazol:

Some of the precautionary measures that are need to be taken while using this medication is:

  • If the woman is pregnant or planning to become pregnant.
  • If the woman is under breastfeeding condition.
  • If the person is having allergy to medicines, foods or other substances.
  • If the person is having history of blood disease polycythemia, blood vessel problems, cancer, diabetes, seizures, fluid retention, heart problems, high blood pressure, high cholesterol levels, liver or kidney problems or migraines etc.

Side effects of drug:

The side effects of the danazol are:

  • Acne, changes in menstrual flow (e.g. spotting), changes in semen volume, decrease in breast size, excessively oily skin, flushing, hair loss etc.
  • Rash,hives,itching,difficulty in breathing, chest tightness, abnormal growth of hairs etc.

Overdose:

Overdosing of medication should not be done. In case if overdosing symptoms occurs, visit to the nearest hospital immediately.

Missed dose:

The missed dose is taken as soon as get remember. But if the time of next dose has been achieved, the missed dose is skipped and the next dosing schedule is followed.

Storage conditions:

The medication should be kept at room temperature. It should be kept away from children and from excess heat and moisture.

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